Organic Chemistry

 


 

OC 203/CD 213(AUG) 3:0

Organic Chemistry-I

 

Electronic effects in organic compounds, aromaticity, frontier orbital theory, steric effects, stereochemistry, conformational analysis. Methods of deducing organic reaction mechanisms, Hammond postulate, Curtin-Hammett principle, linear free energy relationships; Hammett and Taft equations. Organic transformations and molecular rearrangements. Reactive intermediates, classical and nonclassical carbocations, carbanions, free radicals, carbenes, nitrenes, arynes, radical ions, diradicals, concerted reactions, Woodward-Hoffman rules.

 

S Chandrasekhar and Uday Maitra

 

Smith, M.B., March J., March’s Advanced Organic Chemistry: Reactions, Mechanisms and Structure, Sixth Edn, Wiley, 2007.

Carey, F.A., and Sundberg, R.J., Advanced Organic Chemistry, Part A, Fourth Edn, Plenum, 2001.

Lowry, T.M., and Richardson, K.S., Mechanism and theory in Organic Chemistry, Third Edn, Harper and Row, 1986.

Current Literature.

 

 

OC 231 (AUG) 3:0

Chemistry of Biological Systems

 

Molecules of nature: amino acids, nucleic acids, lipids, carbohydrates. Mechanism of action of selected enzymes and coenzymes, enzyme inhibition. Concepts of biological cell, membranes and their components. Different membranous properties, phase-transition, lipid motions, transport in membranes, molecular biology, chemistry of nucleic acid, DNA synthesis, cloning and use of recombinant DNA technology, proteins, immunochemistry, catalytic antibodies. Other important developments in current literature. Requirements include submission of a term paper on a topic current literature and presentation of a seminar.

 

S Bhattacharya and E N Prabhakaran

 

Voet, D., and Voet, J.G., Biochemistry, Second Edn, John Wiley Cysons NY, 1995.

Stryer, L., Biochemistry, Fourth Edn, W H Freeman & Co., NY.

Contemporary literature

 

OC 301 (AUG) 3:0

Advanced Organic Synthesis

 

Planning and synthesis, retrosynthetic analysis-disconnection approach, convergent synthesis, linear synthesis-protecting groups-ring forming strategy-umpolung synthesis- synthesis of natural products. Recent literature in total synthesis of natural products.

 

Kavirayani R Prasad

 

Corey, E.J., and Cheng, X., The Logic of chemical synthesis,  Wiley NY,1989.

Warren, S., Organic Synthesis: The Disconnection Approach, Wiley NY, 1982.

Apsimon, Total Synthesis of Natural Products, Vol. I-IX Wiley Interscience.

Currrent Literature