Molecular Reproduction, Development and Genetics

RD 201/DB 204 (AUG) 2:0

Genetics

Transmission and distribution of genetic materials, dominance relations and multiple alleles, gene interaction and lethality, sex linkage, maternal effects and cytoplasmic heredity, cytogenetics and quantitative inheritance, elements of developmental and population genetics.

Mahadevan S and Arun Kumar

Strickberger, M.W., Genetics,

Suzuki, et al., An Introduction to Genetic Analysis,

Publishers?

RD 202/DB 267 (JAN) 2:0

Gene Expression and Development

Principles of animal development, maternal information, induction, developmental genetics, factors regulating vertebrate development, mammalian development, regulation of gene expression. Evolutionary developmental biology, control of cell and body size, roles of molecular motors during development.

Upendra Nongthomba

Slack, J.M.W., From Egg to Embryo,

Gilbert. S., Developmental Biology,

Wolpert, L., Principles of Development,

Publishers?

RD 203 (AUG) 2:0

Concepts in Endocrinology and Reproduction

Introduction to endocrine principles. Polypeptide and steroid hormones: their biosynthesis, structure and function. Hormones and growth factors in reproduction, receptors and signaling, physiology of mammalian reproduction from gametogenesis to embryogenesis. Molecular regulation of reproduction; hormones in contraception and infertility.

P B Seshagiri, P Kondaiah and R Medhamurthy

References?

RD 204 (AUG) 2:0

Principles of Signal Transduction in Biological Systems

Principles of signal transduction, receptors, second messengers and ion channels in bacteria, yeast, Dictyostelium and mammals. Signal transduction in bacterial chemotaxis and osmoregulation. Signalling mechanisms during sexual differentiation in yeast. Sensory transduction and gene regulation in Dictyostellium. Mammalian signalling mechanisms through protein kinases, second messenger generating systems and ion channels. Signal transduction during fertilization.

Sandhya S Visweswariah and Deepak K Saini

References?

RD 205/BC 208 (JAN) 2:0

Human Molecular Genetics

Human chromosomes, clinical cytogenetics, tools of human molecular genetics, organization of human genome, pattern of Mendelian inheritance, genomic imprinting, uniparental disomy and human genetic disorders, X-inactivation, genetic variation, polymorphism and mutation, gene mapping and linkage analysis, biochemical basis of genetic diseases, genetics of cancer, genetic counseling, prenatal diagnosis.

Arun Kumar and Sathees Raghavan

Strachan and Read, Human Molecular Genetics, 2004. Publisher?

RD 206/MC 210 (JAN) 2:0

Molecular Oncology

Introduction to cancer biology. Immortalization, transformation, metastasis. Causes of cancer, initiators and promoters, carcinogens, tumor viruses, sporadic and familial cancer. Genetic alterations in cancer. Molecular mechanisms of carcinogenesis: cell culture and animal models. Cancer as a tissue: angiogenesis, role of stroma. Cell cycle and cancer: cell cycle checkpoints, cyclins and cyclin dependent kinases, CDK inhibitors. Oncogenes: growth factors, growth factor receptors, G protein/signal transduction, tyrosine and serine/threonine kinases and transcription factors. Tumor suppressor genes. Mismatch repair, telomerase, DNA methylation, protein phosphorylation/dephosphorylation and degradation events. Transformation by RNA and DNA tumor viruses: adenovirus, simian virus 40 and human papilloma virus, oncogene-tumor suppressor interactions. Apoptosis and cancer. Cancer and stem cells.

Annapoorni Rangarajan and Kumar Somasundaram

References?

RD 207(AUG) 0:2

Research Course Details?

Faculty

RD 208 (JAN) 0:2

Research Course II Details?

Faculty